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. 2022 Sep 21;21(12):1835–1845. doi: 10.1158/1535-7163.MCT-21-1021

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 3. α-camera imaging of [225Ac]Ac-DOTA-2Rs15d activity distribution in cryo-sectioned HER2pos tumors (A) and kidneys (B) of subcutaneous SKOV-3 xenografts. All images were taken at 1, 4, and 24 hours p.i. C, Histogram of the activity distribution of an α-camera image of kidneys 4 hours p.i. derived from ROIs encompassing the whole kidney area, including both cortex and medulla. D, Multi-term gaussian plots fitted to the histogram data of cortex ROI. Homogeneity of cortex (E) and tumor (F) was assessed by plots where the total signal fraction is displayed as a function of the total area fraction. A completely uniform ROI corresponds to a linear function (depicted as a dashed line) and an area under the curve (AUC) of 0.5. — α-camera imaging of [²²⁵Ac]Ac-DOTA-2Rs15d activity distribution in cryo-sectioned HER2^pos tumors (A) and kidneys (B) of subcutaneous SKOV-3 xenografts. All images were taken at 1, 4, and 24 hours p.i. C, Histogram of the activity distribution of an α-camera image of kidneys 4 hours p.i. derived from ROIs encompassing the whole kidney area, including both cortex and medulla. D, Multi-term gaussian plots fitted to the histogram data of cortex ROI. Homogeneity of cortex (E) and tumor (F) was assessed by plots where the total signal fraction is displayed as a function of the total area fraction. A completely uniform ROI corresponds to a linear function (depicted as a dashed line) and an area under the curve (AUC) of 0.5.