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. 2022 Sep 21;21(12):1835–1845. doi: 10.1158/1535-7163.MCT-21-1021

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 4. Therapy with [225Ac]Ac-DOTA-2Rs15d improves survival of mice bearing disseminated intraperitoneal SKOV3.IP1 tumors. Treatment schedules (A) and Kaplan–Meier survival plots (B) together with relative body weight (C) in various groups of treated mice. D, Calculated absorbed doses (Gy), without considering of RBE factor 5 for α-particles, in normal organs and tumor for one single therapeutic injection 85 kBq and total therapeutic activity 255 kBq of [225Ac]Ac-DOTA-2Rs15d. H&E sections of kidneys from mice receiving 0.9% NaCl (E), one single dose (F) and three injections (G) of [225Ac]Ac-DOTA-2Rs15d. — Therapy with [²²⁵Ac]Ac-DOTA-2Rs15d improves survival of mice bearing disseminated intraperitoneal SKOV3.IP1 tumors. Treatment schedules (A) and Kaplan–Meier survival plots (B) together with relative body weight (C) in various groups of treated mice. D, Calculated absorbed doses (Gy), without considering of RBE factor 5 for α-particles, in normal organs and tumor for one single therapeutic injection 85 kBq and total therapeutic activity 255 kBq of [²²⁵Ac]Ac-DOTA-2Rs15d. H&E sections of kidneys from mice receiving 0.9% NaCl (E), one single dose (F) and three injections (G) of [²²⁵Ac]Ac-DOTA-2Rs15d.