Table 2.
Histopathologic analysis of kidneys sections from mice enrolled in the dose escalation study.
| Groups (kBq) | ||||
|---|---|---|---|---|
| Control | ||||
| (0 kBq) | 19 kBq | 38 kBq | 75 kBq | |
| Total animals | 3 | 3 | 3 | 3 |
| Tubular cast, hyaline | 1/1.0 | 2/2.0 | 3/1.6 | 3/1.3 |
| Tubular basophilia | 1/1.0 | 0 | 0 | 0 |
| Tubular dilation | 0 | 3/2.6 | 3/3.3 | 3/2.6 |
| Cytoplasmic vacuolation | 0 | 3/2.6 | 3/3.0 | 3/2.6 |
| Tubular necrosis | 0 | 3/3.0 | 3/3.6 | 3/3.3 |
| Tubular regeneration | 0 | 3/4.0 | 3/5.0 | 3/4.3 |
| Fibrosis interstitial | 0 | 3/3.0 | 3/3.0 | 3/3.6 |
| Inflammation | 2/1.0 | 3/2.0 | 3/2.0 | 3/2.6 |
| Mononuclear foci | 1/1.0 | 2/2.0 | 3/1.6 | 3/1.0 |
| Karyomegaly | 0 | 3/1.3 | 3/1.3 | 3/2.0 |
| Glomerular atrophy | 0 | 3/1.3 | 2/1.5 | 3/2.0 |
| Mineralization | 0 | 1/2.0 | 0 | 1/1.0 |
| Pelvis dilation | 1/1.0 | 0 | 0 | 0 |
Note: Kidney sections were stained with H&E. Incidence and mean severity of findings in kidney. Grade 1, minimal; grade 2, slight; grade 3, moderate; grade 4, marked; grade 5, severe; description of the severity scores is detailed in the Supplementary Material.