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. 2022 Sep 16;82(23):4359–4372. doi: 10.1158/0008-5472.CAN-22-1190

Figure 5.

Figure 5.

Validation of potential spatial biomarkers with an independent cohort (presurgically treated). A, Validation of imRS by comparing of OS between short-term group, long-term group, and the validation cohort (log-rank test). B, Comparisons of imRS between the short-term group, long-term group, and validation cohort. *, P < 0.05; ****, P < 0.0001 (Wilcoxon rank-sum test). C, Exemplar topological graph of IL10+ myelomonocytes, PD-1+ CD4+ T cells, and GZMB+ CD8+ T cells in the validation cohort. D, Immunodetection of CD8 and CD20 featuring LAs of B cells and CD8+ T cells. E, Validation of immune cell density by comparing B-cell and CD8+ T-cell densities between short-term and long-term groups, and the validation cohort; ns, not significant; **, P < 0.01 (Wilcoxon rank-sum test). F, Hierarchically clustered heatmap of marker expression compositions in LAs. Bar plot show the B-cell and CD8+ T-cell densities for each LA, respectively. G, imRS was computed at per-cell basis and compared between R and NR groups; ****, P < 0.0001 (Wilcoxon rank-sum test). H, Comparison of CD8+ T-cell density in LAs between R and NR groups.