Figure 6.

Proposed TiME landscape modeling the differences between patients with long-term survival and short-term survival PDAC with regard to immune population activities. In long-term survivors, the immunosuppression activity of IL10⁺ myelomonocytes were hypothesized to be inhibited by their adjacent PD-1⁺CD-4⁺ T cells through IFNg production; in short-term survivors, IL10⁺ myelomonocytes were hypothesized to suppress their adjacent GZMB⁺ CD8⁺ T cells by direct inhibition on cytotoxicity; in addition, low density of CD8⁺ T, rather than B cells, in LAs was also observed in short-term survivors. (Schematics created with BioRender.com.)