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. 2022 Oct 20;10(12):1423–1432. doi: 10.1158/2326-6066.CIR-22-0366

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 2. Illustration of the structure and diversity of Siglecs. There are two main groups of Siglecs, those which are highly conserved, as shown on the left, and a more diverse group of CD33-related Siglecs, as shown on the right. All Siglecs have an extracellular V-type Ig domain and at least one C2-type Ig domain. Many Siglecs also contain at least one cytoplasmic ITIM domain, involved in immunosuppressive signaling. — Illustration of the structure and diversity of Siglecs. There are two main groups of Siglecs, those which are highly conserved, as shown on the left, and a more diverse group of CD33-related Siglecs, as shown on the right. All Siglecs have an extracellular V-type Ig domain and at least one C2-type Ig domain. Many Siglecs also contain at least one cytoplasmic ITIM domain, involved in immunosuppressive signaling.