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. 2022 Sep 13;12(12):2856–2879. doi: 10.1158/2159-8290.CD-22-0603

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©2022 The Authors; Published by the American Association for Cancer Research

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Figure 7. Pathways important in melanoma development. Genomic aberrations are shown in five signaling pathways that are important in melanoma development: MAPK; PI3K, p53, p16–CDK–RB (p16), and telomere maintenance (TELO). Included genes and aberrations for each pathway are listed in Supplementary Table S8. Oncoplots show the type of aberration(s) in a gene within each pathway, and plots are grouped by subtype: A, cutaneous tumors; B, acral tumors; C, mucosal tumors; and D, uveal tumors. The number of pathways mutated and the primary site of the tumor are shown. The color sidebars show the percentage of melanomas with the aberrant pathway. — Pathways important in melanoma development. Genomic aberrations are shown in five signaling pathways that are important in melanoma development: MAPK, PI3K, p53, p16–CDK–RB (p16), and telomere maintenance (TELO). Included genes and aberrations for each pathway are listed in Supplementary Table S8. Oncoplots show the type of aberration(s) in a gene within each pathway, and plots are grouped by subtype. Cutaneous tumors (A) and acral tumors (B), respectively. Mucosal tumors (C) and uveal tumors (D), respectively. The number of pathways mutated and the primary site of the tumor are shown. The color sidebars show the percentage of melanomas with the aberrant pathway.