FIG. 1.

CD4⁺ but not CD8⁺ T lymphocytes are required for growth inhibition of C. neoformans in the brains of immune mice. Brains of immune mice depleted of CD4⁺ T lymphocytes contained significantly more cryptococcal CFU than those of immune mice and CD8-depleted immune mice. Depletion of specific T-cell subsets by antibodies was confirmed by flow cytometric analysis of spleen cells from the treated mice. The data are representative of one of three experiments that yielded similar results. Ab, antibody.