TABLE 2.
CFU present in brains, spleens, and lungs of mice on days 3, 5, and 7 after i.c. infection with C. neoformans
| Day | Treatment | Mean ± SEM CFU/organa
|
||
|---|---|---|---|---|
| Brain | Spleen | Lungs | ||
| 3 | None (untreated) | 9.6 × 104 ± 2.0 × 104bc | 40 ± 15 | 120 ± 46 |
| Saline-IFA | 10.0 × 104 ± 3.8 × 104d | 119 ± 42 | 375 ± 159 | |
| CneF-IFA | 1.4 × 104 ± 0.9 × 104 | 19 ± 13 | 3 ± 3 | |
| 5 | None (untreated) | 5.2 × 106 ± 0.4 × 106bc | 4.5 × 103 ± 968 | 14.6 × 103 ± 4.9 × 103 |
| Saline-IFA | 4.1 × 106 ± 0.7 × 106e | 2.3 × 103 ± 555 | 3.4 × 103 ± 0.5 × 103 | |
| CneF-IFA | 0.14 × 106 ± 0.08 × 106 | 90 ± 30 | 6 ± 4 | |
| 7 | None (untreated) | 11.7 × 106 ± 2.2 × 106bd | 12.8 × 104 ± 0.4 × 104 | 2.1 × 104 ± 1.3 × 104 |
| Saline-IFA | 12.0 × 106 ± 4.6 × 106f | 4.1 × 104 ± 1.5 × 104 | 0.5 × 104 ± 0.1 × 104 | |
| CneF-IFA | 0.06 × 106 ± 0.02 × 106 | 44 ± 18 | 703 ± 284 | |
a
Five mice from each group were examined at each time. The data are representative of one of three experiments with similar results. Statistical comparisons were made by an analysis of variance.
b
Not significant compared to saline-IFA group.
c
P < 0.0003 compared to CneF-IFA group.
d
P < 0.005 compared to CneF-IFA group.
e
P < 0.0005 compared to CneF-IFA group.
f
P < 0.007 compared to CneF-IFA group.