Table 1.
Functional role of the DE lncRNAs in the Immune and Inflammatory response.
| lncRNAs | Expression | Normal Function | Outcome | Reference |
|---|---|---|---|---|
| NIFK-AS1 | Upregulated | Negatively Regulates M2 polarization and Macrophage activation | Suppressed Innate Immunity | (35) |
| NORAD | Negatively regulates cytokine response through miR-485 | Suppressed Inflammatory Response | (36, 37) | |
| SGMS1-AS1 | Negatively regulates cytokine response through miR-106a-5p | (38, 39) | ||
| PRNCR1 | Positively regulates MAPK signaling by CCND2 | Enhanced Adaptive Immunity | (40) | |
| FGD5-AS1 | Downregulated | Positively Regulates M2 polarization and Macrophage activation | Suppressed Innate Immunity | (41) |
| Negatively regulates CD8 T cell activation through PD-L1 expression | Enhanced Adaptive Immunity | (42) | ||
| LUCAT1 | Negative feedback regulator of IFN genes | (30) | ||
| SNHG12 | Negatively regulates CD8 T cell activation through PD-L1 and IL6R | (43) | ||
| SNHG16 | Negatively regulates CD8 T cell activation through CD73 | (44) | ||
| UCA1 | Negatively regulates CD8 T cell activation through PD-L1 | (45) | ||
| MALAT1 | Negatively regulates IL10 mediated immune response | (31) | ||
| Positively regulates TNF-α, IL6, IL1β | Suppressed Inflammatory Response | (10) | ||
| NEAT1 | Positively regulates TNF-α, IL6, IL1β | (10) | ||
| TUG1 | Positively regulates TNF-α, IL6, IL1β | (46) | ||
| UCA1 | Positively regulates TNF-α, IL6, IL1β | (47) |