Scaled scores were based on responses to the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS) survey (version 2.1) and the PROMIS Short Form–Cognitive Function 8a survey. Scores were not adjusted for demographic factors. For each domain, the mean (SD) score in the US was 50 (10) points. For cognitive function, physical, function, and social participation, higher scores are better; for all other measures, lower scores are better. Hashed lines between baseline and follow-up points indicate changes that did not meet the within-group clinically meaningful change of at least 2 points.