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. 2022 Nov 18;13:1041315. doi: 10.3389/fimmu.2022.1041315

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Copyright © 2022 Sultan, Adawi, Kol, McCourt, Adawi, Baram, Tal, Werner, Lev, Snapper, Barel, Konnikova, Somech and Shouval

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alterations in circulating leukocytes in a patient with RIPK1 deficiency. tSNE of Phenograph analysis of PBMCs as a (A) conglomerate of all samples with individual cellular population shown or as (B) density plots of the individual groups. (C) Heatmap of the markers expressed in each cluster on the left-hand-side, cluster abundance as a percent of all leukocytes in the middle and fold change of each cluster for each group shown as compared to the RIPK1-deficient Patient 1. (D, E) Clusters combined by the immune populations indicated. (F) CD4 to Cd8 ratio. Blue arrow-relative reduction and red arrow-relative increase in the RIPK1 patient compared to all other groups.