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. 2022 Nov 18;13:1039103. doi: 10.3389/fphar.2022.1039103

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Copyright © 2022 Long, Chen, Deng, Ning, Yang, Qiao and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of endothelial Fgfr1 improved alveolar development and respiratory metrics in neonatal mice in hyperoxia. (A) Representative images of H&E-stained lungs from vehicle or FGFR1 inhibitor treated mice. The top panel shows low-magnification (scale bar = 100 μm) images, and the bottom panel shows higher-magnification (scale bar = 20 μm) images. (B,C) Quantification of MLI (B) and RAC (C) based on the data in (A). Data are shown as means ± SEMs. n = 6 per group. **p < 0.01, ***p < 0.001, ****p < 0.0001. (D–G) Results of respiratory metrics measurement. Data are shown as means ± SEMs. n = 10 per group. *p < 0.05, **p < 0.01, ****p < 0.0001.