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. 2022 Oct 14;36(12):1371–1383. doi: 10.1177/02698811221125440

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — CBD effects after subchronic treatment on behavior of females rats (during proestrus and late diestrus) in the EPM. Each animal was treated for 4 consecutive days with one injection of vehicle or CBD (0.3 mg/kg). (a) Timeline of the protocol for the experiments, (b) the number of entries into the open and (c) percentage of time spent in the open arms, and (d) the number of entries into closed arms and (e) percentage of time spent in the closed arms of the maze. The data are expressed as the mean ± SEM. Student’s t-test was used to compare treatment effects in each group (P and LD). *p < 0.05, compared to control group. N = 7–10/group. CBD: cannabidiol; EPM: elevated plus maze.