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. 2022 Oct 14;36(12):1371–1383. doi: 10.1177/02698811221125440

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — CBD did not affect the behavior of male and female rats in the open-field test. Each animal was injected 1 h before the test either with vehicle or CBD 0.3, 3, or 30 mg/kg. (a) Timeline of the protocol for the experiments, (b) time spent in the center of the open field, (c) the total number of crossings, and (d) the total number of rearings in the (OF). The data are expressed as the mean ± SEM. There was not a statistically significant difference in the behavioral responses investigated in the open field (p > 0.05) among the mean values for the different treatment groups in females and males. N = 8–12/group. CBD: cannabidiol; OF: open field.