Table 2.
Experiment 2—Effect of CBD administered acutely in females (proestrus and late diestrus) and male rats on ethological parameters measured in the elevated plus maze test.
| Proestrus | ||||||
|---|---|---|---|---|---|---|
| Behavior | Vehicle | CBD 0.3 | CBD 3 | CBD 30 | F (3,30) | p |
| SAP | 10.00 ± 2.33 | 9.71 ± 1.43 | 13.00 ± 1.61 | 8.13 ± 0.79 | 1.15 | 0.35 |
| HD | 14.91 ± 2.49 | 15.14 ± 1.91 | 12.75 ± 0.94 | 11.13 ± 1.73 | 0.86 | 0.47 |
| RE | 14.18 ± 0.95 | 15.00 ± 1.53 | 17.25 ± 1.89 | 16.88 ± 1.76 | 0.36 | 0.39 |
| EAE | 2.90 ± 0.41 | 1.71 ± 0.57 | 1.50 ± 0.38 | 2.62 ± 0.75 | 1.72 | 0.18 |
| Late diestrus | ||||||
| Behavior | Vehicle | CBD 0.3 | CBD 3 | CBD 30 | F (3,29) | p |
| SAP | 9.88 ± 1.84 | 9.00 ± 1.57 | 11.00 ± 1.77 | 14.11 ± 1.40 | 1.94 | 0.15 |
| HD | 10.75 ± 2.23 | 14.38 ± 1.71 | 10.75 ± 1.93 | 10.56 ± 1.68 | 0.92 | 0.44 |
| RE | 15.75 ± 2.48 | 14.38 ± 2.14 | 9.75 ± 2.21 | 11.89 ± 1.54 | 1.58 | 0.21 |
| EAE | 1.25 ± 0.59 | 2.37 ± 0.65 | 1.62 ± 0.56 | 2.33 ± 0.44 | 0.96 | 0.42 |
| Male | ||||||
| Behavior | Vehicle | CBD 0.3 | CBD 3 | CBD 30 | F (3,33) | p |
| SAP | 9.90 ± 1.57 | 8.18 ± 1.64 | 12.88 ± 2.14 | 12.25 ± 1.93 | 1.48 | 0.24 |
| HD | 13.60 ± 1.14 | 15.91 ± 1.46 | 17.38 ± 1.28 | 12.25 ± 2.65 | 1.75 | 0.18 |
| RE | 16.30 ± 2.38 | 19.09 ± 1.67 | 16.50 ± 1.64 | 17.50 ± 1.88 | 0.47 | 0.70 |
| EAE | 1.70 ± 0.34 | 2.73 ± 0.56 | 3.12 ± 0.35 | 1.88 ± 0.77 | 1.62 | 0.20 |
The values are mean ± SEM. One-way ANOVA showed that there was not a statistically significant effect of the treatment (vehicle and CBD 0.3, 3, and 30 mg/kg) upon the ethological parameters of risk assessment and exploration in female and male rats. SAP: stretched-attend postures; HD: head-dipping; RE: rearings; EAE: end-arm exploration; ANOVA: analysis of variance; CBD: cannabidiol.