Name of study; country; year	Nature of study	Associated comorbidity	Intervention	Outcome
Takenoshita et al.10 Japan, 2021	Case report	• Anxiety	• 1 mg Aripiprazole	• 1-year follow-up, she reported she was doing well and was continuing her medication of 1 mg of ARP • At 2-year follow-up, she was in complete remission with medication
Özsoy et al11; Turkey, 2021	Case Report	• MDD with psychotic features	• clomipramine (150 mg/day), • clonazepam (4 mg/day), • escitalopram (20 mg/day), • quetiapine (200 mg/day) • Pimozide (2 mg/day)	• At follow up 5 months later, was beginning to begin taking care of self, and perform activities of daily living independently
Vani and Arumugam12 India, 2020	Case Report	• Anxiety and Polysubstance use	• Psychoeducation • CBT	• After 10 sessions, patient’s daily functioning improved • OVIS Score reduced from 5.7 to 4.4
Jegede et al6; USA, 2018	Case Report		• Pimozide 1 mg/BD • Fluvoxamine 25 mg/day	• 70% symptomatic improvement in patient’s condition was noted after a few days of starting treatment • Her affect was brighter, she went outside her room for meals and group therapy and started socializing too
Albers et al13 USA, 2018	Case Report	• Depression • Chronic Hepatitis C	• Olanzapine (2.5 mg)	patient showed marked improvement in odor identification deficit and odor-evoked parosmia.
Zantvoord et al14; The Netherlands, 2016	Case Report	• generalized anxiety disorder (GAD)	• CBT	In the following months, ORS and GAD symptoms remained in remission
Lim and Wan15 Singapore, 2015	Case series	Case B: • Anxiety	Case A: • CBT only Case B: • Low dose Antipsychotic	Case A: After CBT patient showed a remarkable recovery. Her social anxiety also reduced significantly and she no longer avoided social interaction. Case B: After few doses patient stopped taking medications herself and defaulted further treatment.
Michael et al16 Australia, 2014	Case series	Case 1: • Anxiety Case 2: Anxiety	Case 1: • CBT • Risperidone 3 mg • Sertraline 50 mg Case 2: • Citalopram 40 mg • CBT • Aripiprazole titrated to 10 mg/day	Case 1: 2 months later, patient had no ORS symptoms. Case 2: Complete resolution of symptoms, significant improvement in functioning.
Muffatti et al17; Italy, 2008	Case Report	MDD with psychotic features	• imipramine 100 mg/daily • Aripiprazole 2.5 mg	The patient showed a significant improvement with aripiprazole.
Miranda-Sivelo et al18; Spain, 2013	Case Report	• Axillary, palmar, and plantar bromhidrosis • paranoid schizophrenia	• low-dose risperidone (3 mg/d) • psychotherapy	• extended follow-up of this patient for 7 year • Negative symptoms persisted • ORS resolved.
Chernyak et al19 USA, 2020	Case Report	• Hyperhidrosis	• Psychoeducation • psychotherapy with behavior exposure based technique • Fluoxetine 60 mg • Neurology consult	• 2 years after treatment, her functioning markedly improved • she was able to complete her education and return to work • relationship with family members also improved
Senkal et al20 Turkey, 2015	Case Series	Case 3: MDD Case 4: Depression	Case 1: • Fluoxetine 60 mg/day • Aripiprazole 15 mg/day Case 2: • Sertraline 100 mg/day • Aripiprazole 10 mg/day Case 3: • Sertraline 50 mg/day Case 4: • Venlafaxine 75 mg/day • Aripiprazole 15 mg/day	Case 1: returned to normal life with significant improvement in symptoms Case 2: responded well with significant improvement in her symptoms Case 3: Symptoms diminished after starting treatment and increase in the level of functioning Case 4: Marked improvement in functioning, decreased depressive symptoms.