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. 2022 Oct 31;14(10):e30930. doi: 10.7759/cureus.30930

Table 2. A summary of previous studies.

MC: major complication; PF: pancreatic fistula; NOD: new-onset diabetes; MOF: multiple organ failure; CI: clinical improvement; WON: walled-off necrosis; LAMS: lumen-apposing metal stent; PS: plastic stent; AE: adverse events; QOL: quality of life

Study Study design Patient Comparison Number of patients Outcomes Follow-up time
van Santvoort et al. (2010) [12] Clinical trial, multicenter Necrotizing pancreatitis Primary open necrosectomy and step-up approach 45 X 43 MC or death, PF, NOD, use of pancreatic enzymes, incisional hernia Six months
van Brunschot et al. (2018) [13] Clinical trial, multicenter Necrotizing pancreatitis Endoscopic and surgical step-up approach 51 X 47 MC or death, PF, exocrine and endocrine insufficiency, biliary strictures, wound infections, need for necrosectomy, the total number of interventions, length of hospital and ICU stay, costs, QOL Six months
Bang et al. (2020) [14] Meta-analysis Infected necrotizing pancreatitis Endoscopic and minimally invasive surgery 95 X 89 Mortality, MOF, enterocutaneous fistula, PF NA
Onnekink et al. (2022) [15] Clinical trial Infected necrotizing pancreatitis after six months follow-up Endoscopic and minimally invasive surgery 42 X 41 MC, death pancreaticocutaneous fistula, reinterventions, pancreatic insufficiency, and QOL Seven years
Calo et al. (2022) [20] Meta-analysis WON drainage LAMS and PS 493 X 514 Clinical improvement, AE, mortality NA