Figure 1.

Schematic representation of antithrombotic drug adsorption at the surface of porous polymer beads. The DrugSorb-ATR system incorporates a cartridge filled with biocompatible highly porous polymer beads that can actively remove hydrophobic target compounds via haemoadsorption. The extensive network of pores on the surface of each polymer bead is optimally sized for particular target molecules, and internal channels provide a vast surface area for adsorption. Beads are produced using solid state chemistry and rely on hydrophobic interactions for adsorption, rather than employing ligands, antibodies, cells, or other biologics. Pore size is such that adsorption of larger molecules (e.g. antibodies and albumin) is minimized and cells are excluded.