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. 2022 Jun 28;206(5):596–607. doi: 10.1164/rccm.202106-1503OC

Figure 1.

Figure 1.

TBXA2R (thromboxane–prostanoid receptor) is upregulated in fibroblasts during lung fibrosis. (A) Western blot nondiseased for TBXA2R in lung tissue from patients with idiopathic pulmonary fibrosis (IPF) compared with nondiseased control subjects. (B) Dot plot depicting TBXA2R gene expression in jointly analyzed single-cell RNA sequencing data from explanted lungs of 20 patients with pulmonary fibrosis and 10 nondiseased control subjects (primary data from Reference 6). (C) Representative immunostaining for TBXA2R in IPF and control lung sections. TBXA2R is red, and vimentin is green. (D) Western blot for TBXA2R expression in lungs of mice at baseline and 1–3 weeks after intratracheal bleomycin. (E) Immunostaining for TBXA2R in mouse lung sections at 3 weeks after treatment with vehicle (control) or bleomycin. TBXA2R is red. Scale bar, 50 μm. AT1 = alveolar type 1; AT2 = alveolar type 2; Bleo = bleomycin; cDC = classical dendritic cell; HAS1 = hyaluronan synthase 1; HSP70 = heat shock protein 70; KRT5 = keratin 5; KRT17 = keratin 17; MUC5AC = mucin 5AC, oligomeric mucus/gel-forming; MUC5B = mucin 5B, oligomeric mucus/gel-forming; NK = natural killer; pDC = plasmacytoid dendritic cell; PLIN2 = perilipin 2; SCGB1A1 = secretoglobin family 1A member 1; SCGB3A2 = secretoglobin family 3A member 2.