TABLE 4.
Lack of effect of MR-1 treatment on sepsis and colonization following i.n. inoculation of CBA/N mice with BG9163 pneumococci
| Groupa | Day of assay | Log10 CFU in noseb
|
Lungsb
|
Bloodb
|
|||
|---|---|---|---|---|---|---|---|
| Median | Mean ± SE | Median log10 CFU | +:− | Median log10 CFU | +:− | ||
| MR-1 | 2 | 4.75 | 4.2 ± 0.6 | <1 | 2:4 | <1 | 1:5 |
| Hamster IgG | 2 | 4.25 | 4.2 ± 0.2 | 3.25 | 4:2 | <1 | 2:5 |
| MR-1 | 5 | 3.35 | 3.7 ± 0.7 | <1 | 0:6 | <1 | 0:6 |
| Hamster IgG | 5 | 4.70 | 4.8 ± 0.8 | <1 | 0:6 | <1 | 0:6 |
a
MR-1 protocol: 250 μg of MR-1 on days −1, +1, and 2.
b
CFU values are expressed per nose, per pair of lungs, and per milliliter of blood. No MR-1 values differed from hamster IgG at P < 0.05 for individual comparisons by the Wilcoxon rank sum test. + refers to the number of mice with more than 10 CFU. − refers to the number of mice with less than 10 CFU.