FIG. 4.

Survival of mice following infection with C. albicans Δssk1 mutants (CSSK11-1, CSSK21-1, and CSSK23-1) and parental strain CAF2. Product-limit survival estimates were calculated by the Kaplan-Meier method, and the log rank test was used to examine the homogeneity of survival curves among the four strains. The overall differences in survival among strains were highly statistically significant (P, 0.0001). Individual comparisons did not vary from the overall pattern: CSSK21 > CSSK23 ≈ CSSK11 (P, 0.0001), CSSK21 > CAF2 (P, 0.0003), CSSK23 > CAF2 (P, 0.0003), CSSK11 > CAF2 (P, 0.0005), and CSSK23 ≈ CHK11 (P, 0.50).