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AK117 binding and competitive binding to human CD47. (A) and (B) are binding kinetics of AK117 and Hu5F9-G4 to extracellular domain of human CD47 examined by surface plasmon resonance on a Biacore T200 system. Competitive binding of AK117 to recombinant human CD47 with SIRPα by indirect ELISA (C). AK117 binding activity to CD47 expressed on tumor cells (D-Jurkat, E-Raji) and blocking of recombinant SIRPα interaction with CD47 on tumor cells (F-Jurkat, G-Raji) by flow cytometry.
