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. 2022 Nov 30;10(11):e005517. doi: 10.1136/jitc-2022-005517

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Monotherapy and combo therapy of AK117 demonstrated antitumor activity in vivo. (A, B) Efficacy and body weight change of AK117 in SCID/Beige mice bearing with Raji cells. (C, D) Efficacy and body weight change of AK117 in SCID/Beige mice bearing with MDA-MB-231 tumor cells. (E, F) Efficacy and body weight change of AK117 or combo with AK112 in SCID/Beige mice bearing with MDA-MB-231 cells. Tumor volumes were assessed two times per week. Error bars represent mean±SEM of tumor volumes. Comparisons between groups were analyzed using two-way analysis of variance; *, p<0.05, **, p<0.01.