Table 2.
Demographic characteristics by cohort
| Characteristic | Cohort 4 | Cohort 5 | Cohort 6 |
| N=20 | N=20 | N=16 | |
| Age (range) | 50 (22–78) | 55 (29–77) | 60.5 (22–83) |
| Gender | 15/5 | 13/7 | 14/2 |
| Males/females n/n (%/%) | (75/25) | (65/35) | (70/10) |
| ECOG PS 0/1 | 11/9 | 7/13 | 16/0 |
| n/n (%/%) | (55/45) | (35/65) | (100/0) |
| BRAF V600+ | 7/15 | 7/11 | 5/11 |
| (# positive/available samples) | (−47%) | (−64%) | (45%) |
| Stage | |||
| IIIB | 0 | 0 | 7 |
| IIIC | 9 | 11 | 5 |
| IV | 11 | 9 | 4 |
| M1a | 2 | 2 | 1 |
| M1b | 4 | 4 | 2 |
| M1c | 5 | 3 | 1 |
| Sites of visceral metastases | |||
| Lung | 6 | 5 | 2 |
| Peritoneal | 0 | 1 | 0 |
| Small bowel | 0 | 2 | 1 |
| Central nervous system | 2 | 0 | 0 |
ECOG PS, Eastern Cooperative Oncology Group performance status.