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. 2022 Nov 30;10(11):e005619. doi: 10.1136/jitc-2022-005619

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Pathologic analysis of the tumors in eight treatment groups. (A, B) Representative tumors harvested from different groups, showing the smallest tumor size/weight in the triple combination treatment (RFH+LTX-315 (L-315)+DOX) group, compared with other seven treatment groups (***p<0.001). (A, C–E) The H&E, TUNEL, and Ki-67 staining further confirms a significantly higher tumor necrosis rate, more apoptotic cells (yellow brown dots), and fewer proliferating cells (yellow brown dots) in the triple combination treatment, compared with other seven treatment groups (Scale bars, 20 µm) (***p<0.001). n=6 in each group. Error bars represent SD. RFH, radiofrequency hyperthermia; TUNEL, transferase dUTP nick end labeling.