Table 3.
Brain regions showing seed-based resting-state FC differences of right CN between CM and EM, HCs
| Brain regions | MNI coordinates | Peak F/t value |
Cluster size | Cluster level PFWE corr. |
||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Three group comparison | ||||||
| Cluster 1 | 60 | -33 | -9 | 15.78 | 199 | 0.003 |
| Temporal_Mid_R | ||||||
| Cluster 2 | 12 | -72 | 9 | 11.40 | 172 | 0.005 |
| Calcarine_R | ||||||
| Calcarine_L | ||||||
| Cluster 3 | 42 | 33 | -3 | 13.75 | 116 | 0.026 |
| Frontal_Inf_Orb_R | ||||||
| Frontal_Inf_Tri_R | ||||||
| Cluster 4 | 3 | -3 | 30 | 13.10 | 126 | 0.019 |
| Cingulum_Mid_R | ||||||
| Cluster 5 | 24 | -66 | 63 | 14.12 | 169 | 0.006 |
| Parietal_Sup_R | ||||||
| Parietal_Inf_R | ||||||
| CM > HC | ||||||
| Cluster 1 | 12 | -72 | 9 | 4.48 | 432 | < 0.001 |
| Calcarine_R | ||||||
| Calcarine_L | ||||||
| Lingual_R | ||||||
| Lingual_L | ||||||
| Cluster 2 | 27 | -69 | 60 | 5.19 | 365 | < 0.001 |
| Parietal_Sup_R | ||||||
| Parietal_Inf_R | ||||||
| Precuneus_R | ||||||
| Cluster 3 | 60 | -30 | -12 | 5.43 | 367 | < 0.001 |
| Temporal_Mid_R | ||||||
| Temporal_Inf_R | ||||||
| Temporal_Sup_R | ||||||
| Cluster 4 | 42 | 33 | -3 | 4.75 | 310 | 0.001 |
| Insula_R | ||||||
| Frontal_Inf_Orb_R | ||||||
| Temporal_Pole_Sup_R | ||||||
| Cluster 5 | 6 | 33 | 3 | 4.28 | 138 | 0.025 |
| Cingulum_Ant_R | ||||||
| Cingulum_Ant_L | ||||||
| CM > EM | ||||||
| Cluster 1 | 12 | -30 | 36 | 4.62 | 182 | 0.012 |
| Cingulum_Mid_R | ||||||
| Precuneus_R | ||||||
| Precuneus_L | ||||||
| Cingulum_Ant_L | ||||||
| Cluster 2 | 6 | -42 | 3 | 4.51 | 124 | 0.043 |
| Lingual_R | ||||||
Note: MNI, Montreal Neurological Institute; L, left; R, right; FWE, family-wise error corrected; CM, chronic migraine; EM, episodic migraine. Brain region localizations were performed using Automatic Anatomical Labeling (AAL) atlas and number of voxels of the anatomical regions in which the cluster extents to are reported. The surviving clusters were assigned thresholds at level p < 0.001 and FWE-corrected to p < 0.05 at the cluster level.