Table 1.
Characteristics of Enrolled Patients with Resectable Hepatocellular Carcinoma
| Characteristics | Overall (n = 701) |
|---|---|
| Sexa | |
| Male | 601(85.7) |
| Female | 100(14.3) |
| Age(years)a | |
| <50 | 399(56.9) |
| ≥50 | 302(43.1) |
| BCLC Stagea | |
| 0-A | 343(48.9) |
| B-C | 358(51.1) |
| HBsAga | |
| Negative | 7(1.0) |
| Positive | 694(99.0) |
| HBV-DNA (IU/mL)a | |
| <5×102 | 207(29.5) |
| ≥5×102 | 494(70.5) |
| Liver cirrhosisa | |
| Negative | 295(42.1) |
| Positive | 406(57.9) |
| Tumor numbera | |
| Single | 488(69.6) |
| Multiple | 213(30.4) |
| Tumor size (cm)a | |
| ≤5 | 279(39.8) |
| >5 | 422(60.2) |
| Tumor capsulea | |
| Complete | 685(97.7) |
| Incomplete | 16(2.3) |
| AFP (ng/mL)a | |
| ≤400 | 351(50.1) |
| >400 | 350(49.9) |
| MVIa | |
| Negative | 317(45.2) |
| Positive | 384(54.8) |
| Neu (×109/L)b | 3.61[2.73,4.70] |
| Lym (×109/L)b | 1.70[1.33, 2.12] |
| Plt (×109/L)b | 204.43[158, 264] |
| CRP (mg/L)b | 3.60[1.37,9.75] |
| Alb (g/L)b | 39.40[36.5,42.1] |
| IBIb | 6.44[2.36,24.47] |
| NLRb | 2.09[1.54,2.68] |
| PLRb | 118.37[85.37,166.30] |
| SIIb | 427.30[263.66,675.27] |
| CARb | 0.09[0.03,0.26] |
| PNIb | 48.19[43.95, 52.05] |
| IINSa | |
| 0 | 276(39.4) |
| 1 | 255(36.4) |
| 2 | 124(17.7) |
| 3 | 46(6.5) |
| PIa | |
| 0 | 510(72.8) |
| 1 | 174(24.8) |
| 2 | 17(2.4) |
| GPSa | |
| 0 | 468(66.8) |
| 1 | 189(26.9) |
| 2 | 44(6.3) |
| mGPSa | |
| 0 | 534(76.2) |
| 1 | 123(17.5) |
| 2 | 44(6.3) |
Notes: aCategorical variables are presented as number (percentage). bContinuous variables are presented as median[interquartile range].
Abbreviations: BCLC, Barcelona Clinic Liver Cancer; HBsAg, hepatitis B surface antigen; HBV-DNA, hepatitis B virus DNA; AFP, alpha-fetoprotein; MVI, microvascular invasion; Neu, neutrophil; Lym, lymphocyte; Plt, platelet; CRP, C reactive protein; Alb, albumin; IBI, inflammatory burden index; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet- lymphocyte ratio; SII, systemic immune inflammation index; CAR, C-reactive protein/albumin ratio, PNI, prognostic nutritional index; IINS, inflammation-immunity-nutrition score; PI, prognostic index; GPS, Glasgow Prognostic Score; mGPS, modified Glasgow Prognostic Score.