Table 2.

Mendelian randomization estimates of CHD, HF, and stroke on KOA and HOA.

Exposure	Outcomes	IVW					Weighted median			MR-Egger				F -statistic
		Odds ratio	95% CI	P -value	Q- value	Heterogeneity P-value	Odds ratio	95% CI	P value	Odds ratio	95% CI	P -value	Pleiotropy P-value
CHD	KOA	0.9011	0.8442, 0.9619	0.0018	12.1158	0.1461	0.9126	0.8498, 0.9800	0.0118	0.8949	0.7375, 1.0858	0.2974	0.9420	49.5032
HF		1.2225	0.9861, 1.5158	0.0669	4.3909	0.2222	1.1418	0.9137, 1.427	0.2436	1.0306	0.5458, 1.9461	0.9344	0.6260	45.3623
Stroke		1.0127	0.8964, 1.1441	0.8388	4.0983	0.5353	0.9800	0.8394, 1.1441	0.7981	1.1352	0.4966, 2.5949	0.7787	0.7979	38.4571
CHD	HOA	0.9968	0.9191, 1.081	0.9377	15.3800	0.9962	0.9983	0.9156, 1.0885	0.9692	0.9654	0.7598, 1.2268	0.7818	0.9962	49.5032
HF		1.0412	0.8661, 1.2517	0.6677	5.1707	0.7052	1.1162	0.9117, 1.4822	0.2247	1.1607	0.6618, 2.0357	0.3956	5.1689	43.6276
Stroke		1.1064	0.9100, 1.3452	0.3103	11.0678	0.0863	1.0977	0.8948, 1.3466	0.3714	2.7712	0.7927, 9.6876	0.1713	0.2060	37.5227

CHD, coronary heart disease; HF, heart failure; KOA, knee osteoarthritis; HOA, hip osteoarthritis; IVW, inverse-variance weighted; CI, confidence interval; MR Mendelian randomization; OR, odds ratio.