Figure 4.

Renal mitochondrial fusion and mitophagy in sham and HP-AKI mice. (A) Expression of mitochondrial fusion protein mitofusin 2 (MFN2) is decreased at both 8 and 24 hours after HP-AKI, whereas (B) expression of mitophagy-associated PTEN-induced kinase 1 (PINK1) protein is significantly reduced at 24 hours after HP-AKI compared with sham mice. Densitometry (mean±SEM), normalized for GAPDH expression, is displayed below blots. n=8 and n=10 in sham and HP-AKI groups, respectively, at 8 hours, and n=5 in each group at 24 hours. **P<0.01 and *P<0.05 versus sham group.