FIGURE 6.

a) Schematic illustration of preparing protein-encapsulated CPNCs with sustained release capability. b) In vivo fusion score using a rat spinal fusion model at 8 weeks (nMBP-2: BMP-2-encapsulated CPNC with BMP-2 concentration equivalent to 1.5 μg BMP-2). c) Quantified relative bone volume (BV/TV) resulted from the nBMP-2 versus BMP-2. d) Quantified inflammatory reaction volume and area caused by nBMP-2 versus BMP-2, as measured by MRI and histology, respectively. **p < 0.01, ***p < 0.001. (Adapted with permission from Tian et al. (2016). Copyright 2016, American Chemical Society).

NOTE: For Figure 6a, 6b, 6c, and 6d please refer to Scheme 1, Figure 3a, Figure 3c, and Figure 3g, respectively, of the manuscript by Tian et al.:

Tian, H., Du, J., Wen, J., Liu, Y., Montgomery, S. R., Scott, T. P., … Lu, Y. (2016). Growth-factor nanocapsules that enable tunable controlled release for bone regeneration. ACS Nano, 10(8), 7362-7369.