Figure 2.

Digenic COL4A5 plus COL4A3 or COL4A4 variants in females are associated with a trend to earlier onset of proteinuria (P=0.09). (A) Effect of digenic COL4A5 plus COL4A3/COL4A4 variants on heterotrimer formation in women (16). (B) Proteinuria in women with a COL4A5 variant (37) compared with a COL4A5 plus a COL4A3 or COL4A4 variant (Table 2). The data and references for the digenic variants are summarized in Table 2, and full data are provided in Supplemental Table 2. The COL4A5 variant (solid line) and the COL4A5 plus a COL4A3 or COL4A4 variant (dashed line) are shown.