Table 1.
Overview of study details.
| Author (Year) | Study Design |
Intervention Characteristics |
Outcome Measures |
|||||
|---|---|---|---|---|---|---|---|---|
| Model | RCI model type (acute vs chronic) | Species | Cell type | Total dose | Cell Delivery | Timing of assessment post RCI intervention | Assessment Type | |
| Barco 2014 | Sharp detachment of supraspinatus tendon | Acute | Syngeneic BDIX Rats | Allogenic Adipose-derived stem cells | 2,000,000 | Fibrin sealant | 4, 8 weeks | Ultimate Load Failure Rigidity Ultimate Tensile Strength Energy Absorbed |
| Chen 2015 | Collagenase injection at supraspinatus tendon | Acute | Female Sprague Dawley Rats | Xenogenic Human Adipose-derived stem cells | 3,000,000 | PBS | 3, 7, 14, 21, 28 days | Ultimate Load Failure In-vitro mRNA Expression |
| Degan 2016 | Pressure detachment of supraspinatus tendon | Acute | Athymic Nude Rats | Xenogenic Bone Marrow-derived human MSCs | 1,000,000 | Fibrin sealant | 2, 4 weeks | Ultimate Load Failure Stiffness |
| Gullota 2009 | Sharp detachment of supraspinatus tendon | Acute | Males Lewis Rats | Allogenic Bone Marrow-derived stem cells | 1,000,000 | Fibrin sealant | 2, 4 weeks | Ultimate Load Failure Stiffness Cross-sectional Area Ultimate Tensile Strength Area of Metachromasia Collagen Birefringence MSC Tracking |
| Kaizawa 2019 | Sharp detachment of supraspinatus tendon | Chronic | Male Sprague Dawley Rats | Allogenic “Luciferase-transfected” Adipose-derived stem cells (Luc + ASC) | Not reported | Growth medium | 8 weeks | Ultimate Load Failure Stiffness Micro CT Area of Metachromasia Collagen Birefringence MSC Tracking |
| Kim 2017 | Not reported | Acute | New Zealand White Rabbits | Xenogenic Adipose-derived stem cells | 1,000,000 | Acellular dermal matrix | 8 weeks | Ultimate Load Failure Ultimate Tensile Strength Modified Tendon Maturing Score MSC Tracking |
| Kwon 2018 | Punch biopsy of subscapularis tendon | Chronic | New Zealand White Rabbits | Xenogenic Human Umbilical Cord Blood-derived Mesenchymal Stem Cells (UCB-MSCs) | 1,000,000 | Solution not reported | 4 weeks | Walking Distance Fast Walking time Mean Walking Speed Tear Size |
| Learn 2018 | Sharp detachment of infraspinatus tendon | Acute | New Zealand White Rabbits | Allogenic Bone Marrow from two rabbit femurs | 500,000 | Electrochemically aligned collagen | 3 months | Ultimate Load Failure Stiffness |
| Lipner 2015 | Sharp detachment of supraspinatus tendon | Acute | Sprague Dawley Rats | Allogenic Adipose-derived stem cells | 500,000 | Aligned nanofibrous poly (lactic-co-glycolic acid) scaffold | 14, 28, 56 days | Ultimate Load Failure Stiffnes Ultimate Strain Micro CT Modified Tendon Maturing Score MSC Tracking |
| Liu 2019 | Sharp detachment of infraspinatus tendon | Acute | Mixed Breed Dogs | Autologous Bone Marrow-derived MSCs | 1,000,000 | Tendon-fibrocartilage-bone composite (TFBC) | 6 weeks | Ultimate Load Failure Ultimate Tensile Strength Cross-sectional Area Area of Metachromasia Collagen Birefringence MSC Tracking |
| Oh 2014 | Sharp detachment of subscapularis tendon, the tendon is wrapped in silicone penrose drain | Chronic | New Zealand White Male Rabbits | Allogenic Adipose-derived stem cell | 10,000,000 | Hank's Balanced Salt Solution | 6 weeks | Ultimate Load Failure EMG |
| Omi 2016 | Sharp detachment of supraspinatus tendon | Acute | Adult Female Lewis Rats | Allogenic Bone Marrow stromal cells (BMSC) | 1,000,000 | Composite of multilayer tendon slices (COMTS scaffold) | 6 weeks | Ultimate Load Failure Stiffness MSC Tracking |
| Park 2015 | Punch biopsy of subscapularis tendon | Acute | Male New Zealand White Rabbits | Xenogenic Human Umbilical Vein-derived MSCs | Not reported | Solution not reported | Pre-intervention, 4 weeks | Walking Distance Fast Walking time Mean Walking Speed Tear Size MSC Tracking |
| Rothrauff 2018 | Sharp detachment of supraspinatus and infraspinatus tendons | Acute and Chronic | Adult Male Lewis Rats | Allogenic Adipose-derived stem cells | 1,000,000 | Fibrin sealant or Gelatin methacrylate (GelMA) | 4 weeks | Ultimate Load Failure Stiffness Micro CT |
| Smietana 2017 | Sharp detachment of supraspinatus tendon | Acute and Chronic | Female Fischer Rats | Allogenic Bone Marrow stromal cells from rat femur that was concentrated | Not reported | Tissue engineered tendon | 8 weeks | Ultimate Load Failure Stiffness Area of Metachromasia Collagen Birefringence |
| Tornero 2015 | Sharp detachment of supraspinatus tendon | Chronic | Sprague Dawley Rats | Allogenic Bone marrow-derived stem cells | 1,000,000 | Type 1 collagen membrane | 4, 8 weeks | Ultimate Load Failure Stiffness Max Deformation |
| Valencia 2014 | Sharp detachment of supraspinatus tendon | Acute | Sprague Dawley Rats | Allogenic Adipose-derived MSCs | 2,000,000 | Collagen carrier | 2, 4 weeks | Ultimate Load Failure Stiffness Max Deformation Energy Absorbed Elastic Load MSC Tracking |
| Yokoya 2012 | Sharp detachment of infraspinatus tendon | Acute | Adolescent Japanese White Rabbits | Autologous Bone Marrow-derived MSCs | 5,000,000 | Polyglycolic acid sheed scaffold | 4, 8, 16 weeks | Ultimate Load Failure Ultimate Tensile Strength Cross-sectional Area Young's Modulas Modified Tendon Maturing Score |