Table 2.

Description of the WOMAC domains and the total score according to group and moment of evaluation and result of comparative tests.

Variable/Group	Moment				p Group	p Moment	p Interaction
	Baseline	6 months	12 months	24 months
WOMAC Pain					<0.001	<0.001	0.001
Control
mean ​± ​SD	10.7 ​± ​4.1	9.5 ​± ​4.1	9.8 ​± ​4.5	9.4 ​± ​4.5
median (min.; max.)	11 (1; 20)	10 (1; 17)	10 (0; 20)	10 (1; 20)
Intervention
mean ​± ​SD	10.3 ​± ​3.9	8 ​± ​3.9	7.7 ​± ​3.9	8.1 ​± ​3.9
median (min.; max.)	10 (1; 20)	8 (0; 20)	8 (0; 16)	8 (0; 17)
WOMAC Stiffness					0.001	0.001	0.203
Control
mean ​± ​SD	4.4 ​± ​2	4.1 ​± ​1.9	4.2 ​± ​2	3.9 ​± ​2.1
median (min.; max.)	5 (0; 8)	4 (0; 8)	5 (0; 8)	4 (0; 8)
Intervention
mean ​± ​SD	4.1 ​± ​2	3.2 ​± ​1.8	3.3 ​± ​1.9	3.4 ​± ​1.9
median (min.; max.)	4 (0; 8)	3 (0; 7)	4 (0; 8)	3 (0; 7)
WOMAC Function					<0.001	<0.001	<0.001
Control
mean ​± ​SD	38.2 ​± ​14.3	34.1 ​± ​14.1	35.1 ​± ​14.5	33.6 ​± ​14.2
median (min.; max.)	41 (0; 68)	36.5 (1; 65)	38 (2; 66)	36 (4; 64)
Intervention
mean ​± ​SD	37.3 ​± ​13.8	29.5 ​± ​15.2	27.8 ​± ​13.4	30 ​± ​13.8
median (min.; max.)	40 (1; 68)	33 (0; 63)	30 (0; 60)	34 (0; 54)
WOMAC Total					<0.001	<0.001	<0.001
Control
mean ​± ​SD	53.4 ​± ​19.1	47.8 ​± ​19	49 ​± ​20.3	47 ​± ​19.7
median (min.; max.)	55.5 (4; 96)	51 (2; 89)	52 (3; 94)	50 (5; 89)
Intervention
mean ​± ​SD	51 ​± ​18.2	40.6 ​± ​19.8	38.8 ​± ​17.9	41.3 ​± ​18.2
median (min.; max.)	53 (2; 96)	45 (0; 90)	40 (2; 82)	44 (0; 77)

Generalized equations with Poisson distribution and identity function.

P group ​= ​Differences between groups in each moment.

P moment ​= ​Differences between moments in each group.

P interaction ​= ​differences in curves of the two groups during the study period.