Table 3.

Results of comparisons of WOMAC domains and the total score between groups or moments of evaluation.

Variable	Group/Moment	Comparison	Mean difference	Standard error	p	Effect size	MD CI(95%)
							Low	Upper
WOMAC Pain	Control	Baseline-6 months	1.2	0.28	<0.001		0.33	2.07
		Baseline-12 months	0.89	0.36	0.356		−0.22	2.00
		Baseline-24 months	1.28	0.41	0.047		0.01	2.56
		6 months–12 months	−0.32	0.27	>0.999		−1.17	0.54
		6 months–24 months	0.08	0.36	>0.999		−1.05	1.21
		12 months–24 months	0.40	0.29	>0.999		−0.51	1.31
	Intervention	Baseline-6 months	2.24	0.27	<0.001		1.41	3.08
		Baseline-12 months	2.60	0.34	<0.001		1.55	3.65
		Baseline-24 months	1.98	0.39	<0.001		0.77	3.19
		6 months–12 months	0.36	0.25	>0.999		−0.41	1.13
		6 months–24 months	−0.26	0.33	>0.999		−1.29	0.77
		12 months–24 months	−0.62	0.26	0.469		−1,43	0.19
	Baseline	Control-Intervention	0.37	0.47	>0.999		−1.09	1.83
	6 months	Control-Intervention	1.41	0.43	0.029	0.238	0.07	2.76
	12 months	Control-Intervention	2.09	0.43	<0.001	0.355	0.75	3.42
	24 months	Control-Intervention	1.07	0.45	0.491	0.173	−0.34	2.48
WOMAC Stiffness		Control-Intervention	0.65	0.20	0.001	0.241	0.27	1,03
		Baseline-6 months	0.57	0.16	0.001		0.16	0.98
		Baseline-12 months	0.53	0.19	0.024		0.04	1.02
		Baseline-24 months	0.61	0.20	0.016		0.07	1.14
		6 months–12 months	−0.04	0.15	>0.999		−0.44	0.36
		6 months–24 months	0.03	0.19	>0.999		−0.46	0.52
		12 months–24 months	0.08	0.16	>0.999		−0.34	0.49
WOMAC Function	Control	Baseline-6 months	4.34	0.50	<0.001		2.77	5.91
		Baseline-12 months	3.08	0.65	<0.001		1.06	5.11
		Baseline-24 months	4.26	0.75	<0.001		1.91	6.60
		6 months–12 months	−1.26	0.49	0.295		−2,80	0.28
		6 months–24 months	−0.09	0.66	>0.999		−2.14	1.97
		12 months–24 months	1.17	0.53	0.743		−0.48	2.82
	Intervention	Baseline-6 months	7.62	0.49	<0.001		6.09	9.14
		Baseline-12 months	9.51	0.62	<0.001		7.58	11.43
		Baseline-24 months	7.27	0.72	<0.001		5.03	9.51
		6 months–12 months	1.89	0.45	0.001		0.48	3.30
		6 months–24 months	−0.34	0.61	>0.999		−2.24	1.56
		12 months–24 months	−2.23	0.47	<0.001		−3.7	−0.77
	Baseline	Control-Intervention	0.85	0.89	>0.999		−1.93	3.63
	6 months	Control-Intervention	4.12	0.82	<0.001	0.365	1.55	6.69
	12 months	Control-Intervention	7.27	0.81	<0.001	0.651	4.73	9.81
	24 months	Control-Intervention	3.87	0.86	<0.001	0.329	1.19	6.54
WOMAC total	Control	Baseline-6 months	6.02	0.56	<0.001		4.26	7.78
		Baseline-12 months	4.46	0.73	<0.001		2.16	6.75
		Baseline-24 months	5.97	0.86	<0.001		3.29	8.65
		6 months–12 months	−1.56	0.55	0.131		−3.29	0.16
		6 months–24 months	−0.05	0.75	>0.999		−2.38	2.28
		12 months–24 months	1.52	0.59	0.297		−0.34	3.37
	Intervention	Baseline-6 months	10.01	0.54	<0.001		8.32	11.71
		Baseline-12 months	12.23	0.69	<0.001		10.07	14.39
		Baseline-24 months	9.35	0.81	<0.001		6.81	11.89
		6 months–12 months	2.22	0.50	<0.001		0.65	3.79
		6 months–24 months	−0.66	0.68	>0.999		−2.80	1.48
		12 months–24 months	−2.88	0.53	<0.001		−4.52	−1.24
	Baseline	Control-Intervention	2.37	1.05	0.647		−0.89	5.64
	6 months	Control-Intervention	6.37	0.97	<0.001	0.479	3.35	9.39
	12 months	Control-Intervention	10.15	0.96	<0.001	0.770	7.16	13.15
	24 months	Control-Intervention	5.76	1.01	<0.001	0.416	2.62	8.90

MD CI 95% ​= ​95% confidence interval of the mean difference.