Fig. 4.

Extra cellular matrix components measured after IL-1β stimulation. Levels were measured at day 0, 3, 6, 9, 14 in supernatants harvested from healthy controls (HC) and rheumatoid arthritis (RA) explants incubated with (broken line) and without interleukin (IL)-1β (unbroken line). Duplicate explants were incubated for each stimulation and supernatants were pooled before analyzed, n ​= ​7 (HC, white) n ​= ​6 (RA, black). Mean values ​± ​SEM are shown for each time point and statistical differences were calculated using Mixed effect analysis, comparing the different groups. ∗∗∗∗p ​< ​0.0001.