Fig. 4.

Acute exercise alters metabolic pathways in mouse synovial fluid. Enrichment analysis of metabolite features upregulated (right side) or downregulated (left side) following acute exercise identified significantly different biochemical pathways (FDR-corrected p-value<0.05). Blue bars represent all metabolite features detected in the dataset. Red bars represent metabolite features that were upregulated or downregulated corresponding to the directionality of the pathway (i.e. Leucine catabolim: a total of 9 metabolites in this pathway were detected but only 6 had a fold change less than one corresponding to the directionality of this pathway—downregulated)). Supplemental Tables 1 and 2 show the full lists of perturbed pathways.