Fig. 2.

Effect of PODS® Bone morphogenic protein-7 (BMP-7) on real-time chondrocyte proliferation. Cell proliferation was monitored in real-time using xCELLigence's E-system. This passes an electrical current through a plate and measures impedance. As cells grow, the impedance is modulated by the amount of contact with the plate. This value is converted to a CI, a proxy for cell number. index. Chondrocytes were cultured up to 14 days with PODS-BMP-7 (pBMP-7) (25–200 ​ng/ml equivalent), alongside pEmpty (200 ​ng/ml equivalent), and recombinant BMP-7 (200 ​ng/ml). No media changes were performed over the entire culture period. CI is normalised to the initial cell seeding peak at 4 ​h in (A) and Day 4 in (B). Traces represent the mean CI for each treatment group.