Fig. 5.

Repair of cartilage defect in murine model after intra-articular injection of PODS® crystals. Safranin-O staining of sections from injured joints of 8-week old C57BL/6 mice. A longitudinal, full-thickness cartilage defect was created in the mice with a 27G needle, after which mice were intra-articularly injected with the treatment (all n ​= ​5 per group). Mice sacrificed at eight weeks post-surgery were treated with 18.75 ​ng equivalent PODS-bone morphogenic protein-2 (pBMP-2), pBMP-7 or pEmpty in 0.5% hydrogel. Images show representative repair of cartilage for A 8w control, B 8w pBMP-2 and C 8w pBMP-7. Scale bar 100 ​μm.