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Full thickness cartilage defects of the osteochondral defect model treated with either chondrocytes (CHON) or MSC-chondrocyte co-culture (MIX) embedded in a collagen type I hydrogel. Histological stainings (aggrecan, collagen II and X) of cross sections show the defect area at day 0 and after 28 days of ex vivo culture under normoxic (20% O2) or physiological hypoxic (2% O2) conditions. Scale bar 500 μm.
