Table 2.
Radiologic and histological results. Disc degeneration (DD) and endplate scores (EPC) were graded on MRI at vertebral levels, where biopsies were taken. Control (MC0), Modic type (MC1), and Modic type 2 (MC2) were compared with Kruskal Wallis tests (Kruskal), except for tissue homogeneity/heterogeneity, where a Fisher exact test was performed. P-values of pairwise comparisons were adjusted according to Holm's method. Significant values are highlighted in bold. Power of post-hoc power-analysis is indicated in the last column. MT: Masson-trichrome. αSMA: alpha smooth muscle actin. COL1: type I collagen. COL3: type III collagen. FN: cellular fibronectin. CD105: endoglin. CD90: Thy-1.
| p-value |
|||||||
|---|---|---|---|---|---|---|---|
| MC0 (n = 8) | MC1 (n = 8) | MC2 (n = 6) | Kruskal | MC0-MC1 | MC0-MC2 | MC1-MC2 | |
| DD | 3.69 ± 0.8 | 4.94 ± 0.18 | 4.67 ± 0.41 | 0.001 | < 0.001 | < 0.001 | 0.081 |
| EPS | 2.06 ± 0.62 | 5.75 ± 0.38 | 4.67 ± 1.21 | 0.000 | < 0.001 | < 0.001 | 0.045 |
| cellularity | 1.56 ± 0.68 | 1.13 ± 0.74 | 1.5 ± 0.77 | 0.492 | 0.899 | 0.953 | 0.899 |
| homo/hetero | 6/2 | 1/7 | 2/4 | 0.042 | 0.122 | 1.000 | 0.182 |
| inflammation | 0.38 ± 0.69 | 1.88 ± 1.69 | 0.5 ± 0.77 | 0.081 | 0.105 | 0.807 | 0.158 |
| oedema | 0 ± 0 | 1.13 ± 0.99 | 0.83 ± 0.75 | 0.019 | 0.015 | 0.044 | 0.660 |
| MT | 0.44 ± 0.82 | 2.19 ± 1.53 | 1.58 ± 1.11 | 0.034 | 0.027 | 0.126 | 0.480 |
| αSMA | 0.63 ± 0.44 | 1 ± 0.71 | 1.08 ± 0.2 | 0.166 | 0.479 | 0.199 | 0.479 |
| COL1 | 2.63 ± 1.19 | 3.69 ± 1.75 | 3.25 ± 0.52 | 0.310 | 0.461 | 0.607 | 0.754 |
| COL3 | 5.88 ± 1.03 | 5.94 ± 1.12 | 5.42 ± 1.16 | 0.445 | 0.774 | 0.710 | 0.710 |
| FN | 3.63 ± 1.69 | 4.25 ± 2.55 | 4.17 ± 0.75 | 0.712 | 1.000 | 1.000 | 1.000 |
| CD105 | 1.69 ± 1.33 | 3.19 ± 2.36 | 1.63 ± 1.22 | 0.266 | 0.511 | 0.904 | 0.511 |
| CD90 | 0.13 ± 0.35 | 3.34 ± 2.33 | 1.88 ± 1.7 | 0.005 | 0.001 | 0.052 | 0.130 |