Table 3. Number of “at-risk” patients identified at baseline (n = 370 practices).
| Prescribing safety indicator | At risk of hazardous prescribing (denominator) | Exposed to hazardous prescribing (numerator) | Rate of hazardous prescribing per 1,000 patients at risk | |
|---|---|---|---|---|
| Outcome: GI bleed | ||||
| A | Patients aged ≥65 years prescribed an oral NSAID without coprescription of an ulcer-healing drug | 369,090 | 8,281 | 22 |
| B | Patients aged ≥18 years with a history of peptic ulceration prescribed an oral NSAID without coprescription of an ulcer-healing drug | 20,668 | 471 | 23 |
| C | Patients aged ≥18 years with a history of peptic ulceration prescribed an antiplatelet drug without coprescription of an ulcer-healing drug | 20,668 | 1,638 | 79 |
| D | Patients aged ≥18 years prescribed warfarin or DOAC in combination with an oral NSAID | 51,551 | 635 | 12 |
| E | Patients aged ≥18 years prescribed warfarin or DOAC and an antiplatelet drug in combination without coprescription of an ulcer healing drug | 32,829 | 1,222 | 37 |
| F | Patients aged ≥18 years prescribed aspirin in combination with another antiplatelet drug without coprescription of an ulcer-healing drug | 65,288 | 3,009 | 46 |
| Outcome: Exacerbation of asthma | ||||
| G | Patients aged ≥18 years with a Read code for asthma prescribed a nonselective beta-blocker | 284,523 | 2,692 | 9 |
| H | Patients aged ≥18 years with a Read code for asthma prescribed a long-acting beta-2 agonist inhaler but not also prescribed an inhaled corticosteroid | 5,217 | 868 | 166 |
| Outcome: Heart failure | ||||
| I | Patients aged ≥18 years who have a diagnosis of heart failure prescribed an oral NSAID | 23,842 | 467 | 20 |
| Outcome: Stroke | ||||
| J | Patients aged ≥65 years with a Read code for dementia but no Read code for psychosis prescribed antipsychotic drugs for >6 weeks | 21,931 | 2,094 | 95 |
| Outcome: Kidney Injury | ||||
| K | Patients aged ≥18 years with an eGFR <45 prescribed an oral NSAID | 35,419 | 728 | 21 |
| Composite of all indicators (including all exposures to hazardous prescribing identified by indicators A-K) |
931,026 | 22,105 | 24 | |
| Composite of GI bleed indicators (including all exposures to hazardous prescribing identified by indicators A-F) |
560,094 | 15,256 | 27 | |
DOAC, direct oral anticoagulant; GI, gastrointestinal; NSAID, nonsteroidal anti-inflammatory drug; PPI, proton pump inhibitor.