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. 2022 Nov 16;19(11):e1004133. doi: 10.1371/journal.pmed.1004133

Table 4. Comparing the rate of hazardous prescribing at 6 months and 12 months postintervention to preintervention, adjusted for general practice and calendar time.

Preimplementation 6 Months 12 Months
Outcome Numeratora/Denominatora
(Raw Rateb)
Fitted rateb,c Numeratora/Denominatora
(Raw Rateb)
Fitted rateb,c OR (95% CI)d Numeratora/Denominatora
(Raw Rateb)
Fitted rateb,c OR (95% CI)d
Overall composite 22,503/853,631
(26.4)
26.7
(26.6:26.7)
11,901/591,364
(20.1)
22.3
(22.3:22.4)
0.83
(0.80:0.86)
3,868/201,992
(19.1)
22.7
(22.6:22.8)
0.85
(0.8: 0.90)
GI composite 16,185/515,879
(31.4)
32.4
(32.4:32.4)
7,607/358,349
(21.2)
24.8
(24.8:24.9)
0.76
(0.73:0.80)
2,369/121,534
(19.5)
24.8
(24.7:24.9)
0.76
(0.7: 0.82)
Indicator A 8,977/333,980
(26.9)
26.3
(26.3:26.4)
3,921/233,533
(16.8)
19.3
(19.3:19.4)
0.73
(0.69:0.77)
1,015/78,187
(13.0)
18.1
(17.9:18.2)
0.68
(0.60:0.77)
Indicator B 573/22,484
(25.5)
23.7
(23.6:23.7)
274/14,700
(18.6
19.0
(18.9:19.1)
0.80
(0.69:0.92)
76/5,158
(14.7)
16.9
(16.7:17.2)
0.71
(0.57:0.89)
Indicator C 1,947/22,484
(86.6)
78.9
(78.8:79.0)
954/14,700
(64.9)
63.4
(63.3:63.5)
0.79
(0.73:0.85)
307/5,158
(59.5)
59.4
(59.2:59.5)
0.74
(0.66:0.83)
Indicator D 44,569/44,569
(13.7)
12.0
(11.9:12.1)
470/36,014
(13.1)
11.9
(11.8:12.0)
0.99
(0.88:1.11)
180/12,700
(14.2)
11.2
(11.0:11.4)
0.93
(0.80:1.09)
Indicator E 11,114/28,507
(39.1)
38.4
(38.4:38.5)
578/22,289
(25.9)
27.0
(26.9:27.1)
0.70
(0.62:0.77)
251/7,729
(32.5)
30.4
(30.2:30.5)
0.78
(0.66:0.92)
Indicator F 2,962/63,855
(46.4)
45.4
(45.3:45.4)
1,410/37,113
(38.0)
36.7
(36.7:36.8)
0.80
(0.75:0.86)
540/12,602
(42.9)
39.1
(39.0:39.3)
0.86
(0.76:0.97)
Indicator G 2,311/260,050
(8.9)
7.6
(7.5:7.6)
1,750/178,020
(9.8)
7.3
(7.2:7.4)
0.96
(0.91:1.02)
710/62,689
(11.3)
7.7
(7.6:7.8)
1.02
(0.94:1.11)
Indicator H 884/5,571
(158.7)
184.6
(184.5:184.7)
504/2,961
(170.2)
194.0
(193.8:194.1)
1.06
(0.95:1.19)
120/688
(174.4)
165.9
(165.7:166.2)
0.88
(0.70:1.10)
Indicator I 498/22,019
(22.6)
20.5
(20.4:20.5)
285/16,120
(17.7)
18.2
(18.1:18.4)
0.89
(0.80:0.99)
91/5,238
(17.4)
16.8
(16.6:17.1)
0.82
(0.66:1.02)
Indicator J 1,903/19,837
(95.9)
81.6
(81.5:81.7)
1,358/14,476
(93.8)
86.6
(86.5:86.7)
1.07
(0.99:1.15)
461/4,843
(95.2)
93.8
(93.7:93.9)
1.16
(1.04:1.30)
Indicator K 722/30,275
(23.9)
20.6
(20.5:20.7)
397/21,438
(18.5)
19.3
(19.1:19.4)
0.93 (0.83:1.05) 117/7,000
(16.7)
17.1
(16.9:17.3)
0.83
(0.68:1.00)

aNumber at risk and preintervention rates estimated as mean over the 4 quarters prior to intervention at each site.

bRate per 1,000 patients at risk.

cFitted rates are adjusted for calendar time and general practice.

dOdds ratio relative to preimplementation.