Figure 10. Case 10 — least challenging lesion:
visual assessment of lesion-centered RoI registration showing the subtraction between the initial and registered follow-up image at each registration stage. a) centroid alignment; b) intensity-based rigid registration; c) feature-based rigid registration; d) landmark-based rigid transformation; e) intensity-based affine registration; f) feature-based affine registration (with black box outlining the lesion); g) deformable registration (with black box outlining the lesion); h) landmark-based 12 DoF affine transformation (note lung boundary misalignment caused by the projective transformation component.
