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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Comput Methods Biomech Biomed Eng Imaging Vis. 2021 Nov 8;10(5):521–539. doi: 10.1080/21681163.2021.1994471

Figure 11. Case 3 — a common lesion:

Figure 11.

visual assessment of lesion-centered RoI registration showing the subtraction between the initial and registered follow-up image at each registration stage: a) centroid alignment; b) intensity-based rigid registration; c) feature-based rigid registration; d) landmark-based rigid transformation; e) intensity-based affine registration; f) feature-based affine registration (with black box outlining the lesion); g) deformable registration (with black box outlining the lesion); h) landmark-based affine with projective transformation. Note that the landmark-based rigid least-square fit transformation serves as a control, since the projective components of the 12 DoF affine transformation led to unreliable alignment (depicted by the projective transformation effect visible around the lung boundary), despite the lower TRE computed across the fiducials.