Figure 4.

A pairwise multi-comparison test across all patients between the six registration methods (centroid alignment, imtensity and feature-based rigid registration, intensity- and feature-based affine registration, and non-rigid, deformable registration) and the two RoIs (lung- and lesion-centeres RoI). Note that the lesion-centered RoI TRE is significantly lower than the lung-centered RoI TRE for all registration methods, with the exception of the deformable registration, which is local in nature and hence not susceptible to the selected RoI, and the rigid LSE, which only depends on the fiducial configuration.