Figure 8.

Affine feature-based (red) vs. deformable (blue) median TRE for lung- (left) and lesion-centered (right) RoI registration. Also shown is the landmark-based rigid least squared fit TRE (black) treated as control. Note that since the Case 12 lesion was co-located within the same lung as the Case 11 lesion, but remote from the Case 11 lesion, and all selected landmarks were in the vicinity of the Case 11 lesion, hence the deformable registration operating on the Case 12 lesion-centered RoI could not be evaluated. Therefore, this figure only illustrates the median TRE achieved across 11 cases under feature-based affine, deformable and rigid least-square fit registration.