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. Author manuscript; available in PMC: 2022 Dec 2.
Published in final edited form as: Prog Polym Sci. 2019 Jul 12;98:101147. doi: 10.1016/j.progpolymsci.2019.101147

Fig. 4.

Fig. 4.

Modulation of cell adhesion using electro-responsive substrates. (A) Electro-cleavage of cell adhesion peptide upon oxidation of silyl hydroquinone to benzoquinone. (B) Electro-mediated assembly/disassembly of WGG-modified RGD (guest) to Cucurbit [8]uril (host) immobilized on a gold substrate. (C) Electro-mediated masking/demasking of RGD ligand spatially. (D) Electro-mediated “On” and “OFF” switching of biomolecular recognition between positively charged Biotin-KKKKC peptide and Avidin. (E) Electro-switchable cell adhesion: (a) functionalization of the substrate with alkoxyamine-RGD-alkyne via Huisgen cycloaddition; (b) electro-mediated oxidation of hydroquinone to benzoquinone induced oxime ligation between alkoxyamine and benzoquinone to form a cyclic structure that enhances cell spreading; (c) electro-reduction induced opening of the cyclic structure. A: [199], Copyright 2003. Reproduced with permission from American Chemical Society. B: [241], Copyright 2012. Reproduced with permission from John Wiley and Sons Inc. C: [243], Copyright 2012. Reproduced with permission from John Wiley and Sons Inc. D: [245], Copyright 2010. Reproduced with permission from John Wiley and Sons Inc. E: [247], Copyright 2011. Reproduced with permission from American Chemical Society.