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. Author manuscript; available in PMC: 2022 Dec 2.
Published in final edited form as: Prog Polym Sci. 2019 Jul 12;98:101147. doi: 10.1016/j.progpolymsci.2019.101147

Fig. 9.

Fig. 9.

Reversible modulation of mechanical stiffness using different types of pH-responsive hydrogels. (A) Mechanical modulation via pH-responsive PDPA50-b-PMPC250-b-PDPA50 triblock copolymer based on ionizable functionalities. (B) Mechanical modulation via pH-induced thioester exchange. (C) pH-induced reversible binding between phenylboronic acid- and cis-diol-containing PEG macromers. (D) Mechanical modulation via pH-dependent folding/unfolding of DNA-incorporating hydrogels: (a) development of two different DNA-conjugated PIC via SPAAC; (b) hydrogel formation using DNA crosslinker incorporating the complementary sequence of the other DNAs. A: [278], Copyright 2011. Reproduced with permission from American Chemical Society. B: [147], Copyright 2018. Reproduced with permission from Elsevier Inc. C: [279], Copyright 2015. Reproduced with permission from John Wiley and Sons Inc. D: [280], Copyright 2017. Reproduced with permission from American Chemical Society.