Figure 2.

The tumor repressor or driver role of ZHX2 in cancer. In HCC, ZHX2 has a context-dependent role. ZHX2 inhibits HCC via multiple mechanisms, but whole body knockout of Zhx2 reduces DEN-induced liver tumors indicating its complex roles. In HCC, lung cancer, multiple myeloma, HL, and thyroid cancer, ZHX2 acts as a tumor suppressor and transcriptionally represses AFP, GPC3, Cyclin A/E, LPL, KDM2A, and S100A14 expression via interacting with NF-YA or other unknown partners to restrict cancer progress. However, in ccRCC and TNBC, ZHX2 plays an oncogenic driver role by interacting with p65 and HIF1α to activate oncogenic signaling. Created using Biorender.com.